HORDB

ID: hor006453
Uniprot ID: Q08535
Protein name: Secretin
Gene name: Sct
Organism: Mus musculus (Mouse)
Family: Glucagon family
Source: animal
Expression: Highly expressed in the intestine .
Disease: NA
Comments: NA
Taxonomy: Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea , Myomorpha (suborder), Rodentia (order), Glires , Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0001664 G protein-coupled receptor binding; GO:0005102 signaling receptor binding; GO:0005179 hormone activity; GO:0046659 digestive hormone activity
GO BP: GO:0002024 diet induced thermogenesis; GO:0007165 signal transduction; GO:0007420 brain development; GO:0008542 visual learning; GO:0009992 intracellular water homeostasis; GO:0021542 dentate gyrus development; GO:0021766 hippocampus development; GO:0031667 response to nutrient levels; GO:0032098 regulation of appetite; GO:0043524 negative regulation of neuron apoptotic process; GO:0051402 neuron apoptotic process; GO:0097150 neuronal stem cell population maintenance
GO CC: NA

Sequence: HSDGMFTSELSRLQDSARLQRLLQGLV
Length: 27(32-58)
Propeptide: MEPPLPTPMLLLLLLLLSSSAALPAPPRTPRHSDGMFTSELSRLQDSARLQRLLQGLVGKRSEQDTENIPENSLARSKPLEDQLCLLWSNTQTLQDWLLPRLSLDGSLSLWLPPGPRSAVDRSEWTETTRPPR
Signal peptide: MEPPLPTPMLLLLLLLLSSSAA
Modification: T27 Valine amide
Glycosylation: NA
Mutagenesis: NA

Function: Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:20578263, PubMed:20739612, PubMed:20927047, PubMed:30449620). Exerts its biological effects by binding to secretin rec
Mechanism: NA
Cross BBB: NA
Target: Sctr
Target Unid: Q5FWI2
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006453_AF2.pdb

hor006453_ESM.pdb

Mass:	352241	Formula:	C130H217N41O42S
Absent amino acids:	CIKNPWY	Common amino acids:	L
pI:	7.55	Basic residues:	4
Polar residues:	7	Hydrophobic residues:	9
Hydrophobicity:	-32.96	Boman Index:	-6388
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	101.11
Instability Index:	7438.52	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 8179583
Title: cDNA sequence and genomic organization of mouse secretin.
PubMed ID: 18534766
Title: Impaired hippocampal synaptic function in secretin deficient mice.
PubMed ID: 20578263
Title: Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct
PubMed ID: 21159798
Title:
PubMed ID: 20739612
Title:
PubMed ID: 20927047
Title:
PubMed ID: 24273196
Title:
PubMed ID: 30449620
Title: